In 2006, a novel method for extracting functional ventilation-weighted lung images using MRI was published. The method exploited the naturally occurring density changes in the lung during breathing and the resulting images showed a clear clinical potential. A decade later, the method has been adapted and further developed by several research groups and has led to many encouraging pre-clinical studies, both in animals and in humans. In this paper we show the development of the method and summarize the current state-of-the-art, aiming to both inform and motivate students and researchers with an interest in this exciting field.
Keywords: Fourier-Decomposition; Fourier-decomposition; Lung MRI; Lungen-MRT; Ventilation; ventilation.
Copyright © 2016. Published by Elsevier GmbH.