Cyclen lanthanide-based micellar structures for application as luminescent [Eu(iii)] and magnetic [Gd(iii)] resonance imaging (MRI) contrast agents

Esther M Surender; Steve Comby; Sarah Martyn; Brenton Cavanagh; T Clive Lee; Dermot F Brougham; Thorfinnur Gunnlaugsson

doi:10.1039/c6cc03092k

Cyclen lanthanide-based micellar structures for application as luminescent [Eu(iii)] and magnetic [Gd(iii)] resonance imaging (MRI) contrast agents

Chem Commun (Camb). 2016 Sep 18;52(72):10858-61. doi: 10.1039/c6cc03092k. Epub 2016 Aug 15.

Authors

Esther M Surender¹, Steve Comby, Sarah Martyn, Brenton Cavanagh, T Clive Lee, Dermot F Brougham, Thorfinnur Gunnlaugsson

Affiliation

¹ School of Chemistry, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. [email protected].

PMID: 27523566
DOI: 10.1039/c6cc03092k

Abstract

The synthesis of coordinatively unsaturated tetra-substituted 1,4,7,10-tetraazacyclododecane (cyclen) lanthanide complexes is described; these structures, possessing hydrophobic (C12-alkyl) tails and hydrophilic head groups, self-assemble into supramolecular micellar structures in aqueous solution, and hence can be utilised as novel contrast agents for MRI.

MeSH terms

Contrast Media / chemistry*
Coordination Complexes / chemistry*
Cyclams
Europium / chemistry
Gadolinium / chemistry
Heterocyclic Compounds / chemistry
Hydrophobic and Hydrophilic Interactions
Ions / chemistry
Lanthanoid Series Elements / chemistry*
Luminescent Measurements*
Magnetic Resonance Imaging*
Micelles*

Substances

Contrast Media
Coordination Complexes
Cyclams
Heterocyclic Compounds
Ions
Lanthanoid Series Elements
Micelles
Europium
cyclen
Gadolinium