GM-CSF as successful salvage therapy of metamizole (dipyrone)-induced agranulocytosis with Fournier's gangrene and severe septic shock in an adolescent

Annegret Winkler; Silke Kietz; Hagen Bahlmann; Gunel Jafarzade; Holger N Lode; Matthias Heckmann

doi:10.1002/ccr3.616

GM-CSF as successful salvage therapy of metamizole (dipyrone)-induced agranulocytosis with Fournier's gangrene and severe septic shock in an adolescent

Clin Case Rep. 2016 Jul 20;4(8):816-9. doi: 10.1002/ccr3.616. eCollection 2016 Aug.

Authors

Annegret Winkler¹, Silke Kietz², Hagen Bahlmann¹, Gunel Jafarzade³, Holger N Lode², Matthias Heckmann¹

Affiliations

¹ Division of Neonatology and Pediatric Intensive Care Department of Pediatrics and Adolescent Medicine Medical University of Greifswald Greifswald Germany.
² Division of Pediatric Hematology and Oncology Department of Pediatrics and Adolescent Medicine Medical University of Greifswald Greifswald Germany.
³ Division of Pediatric Surgery Department of Pediatrics and Adolescent Medicine Medical University of Greifswald Greifswald Germany.

Abstract

This case report describes the successful use of granulocyte and macrophage colony-stimulating factor as salvage therapy and an alternative to hematopoietic stem cell transplantation in a 14-year-old adolescent with metamizole (dipyrone)-induced agranulocytosis and severe septic shock.

Keywords: Agranulocytosis; filgrastim; metamizole (dipyrone); sargramostim; septic shock.

Publication types

Case Reports