The Combined Usefulness of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting Intravenous Immunoglobulin Resistance with Kawasaki Disease

Yoichi Kawamura; Seiichiro Takeshita; Takashi Kanai; Yusuke Yoshida; Shigeaki Nonoyama

doi:10.1016/j.jpeds.2016.07.035

The Combined Usefulness of the Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Predicting Intravenous Immunoglobulin Resistance with Kawasaki Disease

J Pediatr. 2016 Nov:178:281-284.e1. doi: 10.1016/j.jpeds.2016.07.035. Epub 2016 Aug 12.

Authors

Yoichi Kawamura¹, Seiichiro Takeshita², Takashi Kanai³, Yusuke Yoshida¹, Shigeaki Nonoyama¹

Affiliations

¹ Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan.
² Division of Nursing, National Defense Medical College, Tokorozawa, Saitama, Japan. Electronic address: [email protected].
³ Department of Pediatrics, National Defense Medical College, Tokorozawa, Saitama, Japan; Department of Pediatrics, Japan Self-Defense Forces Central Hospital, Setagaya, Tokyo, Japan.

PMID: 27526622
DOI: 10.1016/j.jpeds.2016.07.035

Abstract

The laboratory records of 405 patients with Kawasaki disease before and after intravenous immunoglobulin (IVIG) therapy were compared between the IVIG-responsive (n = 320) and IVIG-resistant (n = 85) groups. A high neutrophil-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio before IVIG, especially when combined, were useful predictors for IVIG resistance in Kawasaki disease.

Keywords: coronary artery abnormality; white blood cell.

MeSH terms

Blood Cell Count / methods*
Blood Platelets / cytology*
Child, Preschool
Drug Resistance*
Female
Humans
Immunoglobulins, Intravenous / therapeutic use
Infant
Lymphocytes / cytology*
Male
Mucocutaneous Lymph Node Syndrome / blood*
Mucocutaneous Lymph Node Syndrome / drug therapy
Neutrophils / cytology*
Predictive Value of Tests
Retrospective Studies
Sensitivity and Specificity

Substances

Immunoglobulins, Intravenous