Cytosolic DNA Sensing: The Field Narrows

Russell E Vance

doi:10.1016/j.immuni.2016.08.006

Cytosolic DNA Sensing: The Field Narrows

Immunity. 2016 Aug 16;45(2):227-8. doi: 10.1016/j.immuni.2016.08.006.

Author

Russell E Vance¹

Affiliation

¹ Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: [email protected].

PMID: 27533006
DOI: 10.1016/j.immuni.2016.08.006

Abstract

The innate response to many pathogens involves type I interferon production that is initiated upon cytosolic detection of double-stranded DNA (dsDNA), but how dsDNA is detected is controversial. In this issue of Immunity, Gray et al. (2016) use genetics to bring some much-needed clarity to the field.

Publication types

Comment

MeSH terms

Cytosol*
DNA / immunology*

Substances

DNA

Grants and funding

HHMI/Howard Hughes Medical Institute/United States