Feeling Worn Out? PGC1α to the Rescue for Dysfunctional Mitochondria in T Cell Exhaustion

Maria L Balmer; Christoph Hess

doi:10.1016/j.immuni.2016.07.024

Feeling Worn Out? PGC1α to the Rescue for Dysfunctional Mitochondria in T Cell Exhaustion

Immunity. 2016 Aug 16;45(2):233-5. doi: 10.1016/j.immuni.2016.07.024.

Authors

Maria L Balmer¹, Christoph Hess²

Affiliations

¹ Department of Biomedicine, Immunobiology, University and University Hospital Basel, 4031 Basel, Switzerland.
² Department of Biomedicine, Immunobiology, University and University Hospital Basel, 4031 Basel, Switzerland. Electronic address: [email protected].

PMID: 27533009
DOI: 10.1016/j.immuni.2016.07.024

Abstract

In chronic viral infections and cancer, T cells acquire a functional state characterized by reduced effector functionality, termed exhaustion. In two related studies by Scharping et al. (2016) and Bengsch et al. (2016) in this issue of Immunity, dysfunctional mitochondria are identified as a key correlate of CD8(+) T cell exhaustion.

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MeSH terms

CD8-Positive T-Lymphocytes / immunology*
Emotions
Humans
Mitochondria
Transcription Factors*
Virus Diseases / immunology

Substances

Transcription Factors