The role of biophysical properties of provisional matrix proteins in wound repair

Matrix Biol. 2017 Jul:60-61:124-140. doi: 10.1016/j.matbio.2016.08.004. Epub 2016 Aug 14.

Abstract

Wound healing is a complex, dynamic process required for maintaining homeostasis in an organism. Along with being controlled biochemically, wound healing is also controlled through the transduction of biophysical stimuli through cell interactions with the extracellular matrix (ECM). This review provides an overview of the ECM's role in the wound healing process and subsequently expands on the variety of roles biophysical phenomenon play.

Keywords: Biophysics; Collagen; Extracellular matrix; Fibrin; Fibrinogen; Fibronectin; Platelets; Transforming growth factor beta; Wound healing.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Platelets / cytology
  • Blood Platelets / drug effects
  • Blood Platelets / metabolism
  • Cell Communication / drug effects
  • Cell Proliferation / drug effects
  • Collagen / chemistry
  • Collagen / genetics
  • Collagen / metabolism*
  • Dermis / injuries
  • Dermis / metabolism
  • Dermis / pathology
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects
  • Epithelial Cells / metabolism
  • Extracellular Matrix / drug effects
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix / ultrastructure
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Fibroblasts / metabolism*
  • Fibronectins / chemistry
  • Fibronectins / genetics
  • Fibronectins / metabolism*
  • Gene Expression
  • Humans
  • Integrins / chemistry
  • Integrins / genetics
  • Integrins / metabolism*
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / metabolism
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Keratinocytes / cytology
  • Keratinocytes / drug effects
  • Keratinocytes / metabolism
  • Protein Subunits / chemistry
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Wound Healing / drug effects
  • Wound Healing / physiology*

Substances

  • Fibronectins
  • Integrins
  • Intercellular Signaling Peptides and Proteins
  • Protein Subunits
  • Collagen