Drug Delivery by Controlling a Supramolecular Host-Guest Assembly with a Reversible Photoswitch

Nuno Basílio; Uwe Pischel

doi:10.1002/chem.201603331

Drug Delivery by Controlling a Supramolecular Host-Guest Assembly with a Reversible Photoswitch

Chemistry. 2016 Oct 17;22(43):15208-15211. doi: 10.1002/chem.201603331. Epub 2016 Sep 6.

Authors

Nuno Basílio¹, Uwe Pischel²

Affiliations

¹ Laboratório Associado para a Química Verde (LAQV), Rede de Química e Tecnologia (REQUIMTE), Departmento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. [email protected].
² CIQSO - Center for Research in Sustainable Chemistry and, Department of Chemistry, University of Huelva, Campus de El Carmen s/n, 21071, Huelva, Spain. [email protected].

PMID: 27535897
DOI: 10.1002/chem.201603331

Abstract

The reversibly switchable trans-chalcone/flavylium photochromic system was successfully coupled to the complexation equilibrium of a drug-cucurbit[7]uril host-guest assembly. Hence, the phototriggered release of memantine under illumination at 366 nm was observed. The process can be partially reverted through a thermally activated back reaction.

Keywords: cucurbiturils; drug delivery; flavylium; host-guest chemistry; photochemistry.