Data on the expression of cellular lncRNAs in human adenovirus infected cells

Maoshan Chen; Hongxing Zhao; Sara Bergström Lind; Ulf Pettersson

doi:10.1016/j.dib.2016.06.053

Data on the expression of cellular lncRNAs in human adenovirus infected cells

Data Brief. 2016 Jul 5:8:1263-79. doi: 10.1016/j.dib.2016.06.053. eCollection 2016 Sep.

Authors

Maoshan Chen¹, Hongxing Zhao², Sara Bergström Lind³, Ulf Pettersson²

Affiliations

¹ Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia.
² The Beijer Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, S-751 85 Uppsala, Sweden.
³ Department of Chemistry-BMC, Analytical Chemistry, Science for Life Laboratory, Uppsala University, Box 599, SE-751 24 Uppsala, Sweden.

Abstract

Expression of cellular long non-coding RNAs (lncRNAs) in human primary lung fibroblasts (IMR-90) during the course of adenovirus type 2 (Ad2) infection was studied by strand-specific whole transcriptome sequencing. In total, 645 cellular lncRNAs were expressed at a significant level and 398 of them were changed more than 2-fold. The changes in expression followed a distinct temporal pattern. Significantly, 80% of the changes occurred at the late phase and 80% of the de-regulated lncRNAs were up-regulated. The three largest groups of deregulated lncRNAs were 125 antisense RNAs, 111 pseudogenes and 85 long intergenic non-coding RNAs (lincRNAs). Lastly, more than 36% of lncRNAs have been shown to interact with RNA binding proteins.

Keywords: Adenovirus; IMR-90; IncRNA; Long noncoding RNA.