Integrating genomic information with protein sequence and 3D atomic level structure at the RCSB protein data bank

Bioinformatics. 2016 Dec 15;32(24):3833-3835. doi: 10.1093/bioinformatics/btw547. Epub 2016 Aug 22.

Abstract

The Protein Data Bank (PDB) now contains more than 120,000 three-dimensional (3D) structures of biological macromolecules. To allow an interpretation of how PDB data relates to other publicly available annotations, we developed a novel data integration platform that maps 3D structural information across various datasets. This integration bridges from the human genome across protein sequence to 3D structure space. We developed novel software solutions for data management and visualization, while incorporating new libraries for web-based visualization using SVG graphics.

Availability and implementation: The new views are available from http://www.rcsb.org and software is available from https://github.com/rcsb/.

Contact: [email protected] information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Amino Acid Sequence
  • Computational Biology / methods*
  • Computer Graphics
  • Databases, Protein*
  • Genomics
  • Humans
  • Protein Conformation*
  • Software*
  • User-Computer Interface