Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy

Yan Li; Ruilong Zhang; Zhiguo Lu; Guanghui Ma; Lei Chen; Qunwei Tang; Xin Zhang

doi:10.1002/smll.201601932

Microenvironment-Responsive Three-Pronged Approach Breaking Traditional Chemotherapy to Target Cancer Stem Cells for Synergistic Inoperable Large Tumor Therapy

Small. 2016 Oct;12(40):5516-5523. doi: 10.1002/smll.201601932. Epub 2016 Aug 24.

Authors

Yan Li¹, Ruilong Zhang^{1

2}, Zhiguo Lu^{1

3}, Guanghui Ma¹, Lei Chen⁴, Qunwei Tang⁵, Xin Zhang⁶

Affiliations

¹ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
² Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China.
³ University of Chinese Academy of Science, Beijing, 100190, P. R. China.
⁴ Department of Obstetrics and Gynecology, Navy General Hospital of People Liberation Army, Beijing, 100048, P. R. China.
⁵ Institute of Materials Science and Engineering, Ocean University of China, Qingdao, 266100, P. R. China. [email protected].
⁶ State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. [email protected].

PMID: 27552926
DOI: 10.1002/smll.201601932

Abstract

Three-pronged nanoparticles (NPs) that can efficiently prohibit the proliferation of large tumor are developed for inoperable large tumor therapy. The NPs achieve spatially and temporally controlled release of drugs in target sites. The NPs induce the apoptosis of differentiated cancer cells, cancer stem cells, and vascular niches simultaneously. Importantly, the three-pronged NPs inhibit the growth of large tumors without recurrence.

Keywords: cancer stem cells; cancer therapy; hypoxia; inoperable large tumors; three-pronged therapeutic approach; vascular niches.

MeSH terms

Animals
Carcinogenesis / pathology
Human Umbilical Vein Endothelial Cells
Humans
MCF-7 Cells
Mice, Nude
Nanoparticles / chemistry
Nanoparticles / ultrastructure
Neoplasms / drug therapy
Neoplasms / pathology*
Neoplasms / surgery
Neoplasms / therapy*
Neoplastic Stem Cells / pathology*
Tumor Microenvironment*