A peptidome-based phylogeny pipeline reveals differential peptides at the strain level within Bifidobacterium animalis subsp. lactis

Food Microbiol. 2016 Dec:60:137-41. doi: 10.1016/j.fm.2016.06.015. Epub 2016 Jun 29.

Abstract

Bifidobacteria are gut commensal microorganisms belonging to the Actinobacteria group. Some specific strains of Bifidobacterium animalis subsp. lactis are used in functional foods as they are able to exert health-promoting effects in the human host. Due to the limited genetic variability within this subspecies, it is sometimes difficult for a manufacturer to properly track its strain once included in dairy products or functional foods. In this paper, we present a peptidome-based analysis in which the proteomes of a set of B. animalis subsp. lactis strains were digested in silico with human gut endopeptidases. The molecular masses were compared along all the strains to detect strain-specific peptides. These peptides may be interesting towards the development of methodologies for strain identification in the final product.

Keywords: Bifidobacterium animalis subsp. lactis; Peptidome; Specific peptides.

MeSH terms

  • Bacterial Proteins / analysis*
  • Bacterial Proteins / genetics
  • Bifidobacterium animalis / chemistry*
  • Bifidobacterium animalis / classification
  • Bifidobacterium animalis / genetics
  • Bifidobacterium animalis / isolation & purification*
  • Computer Simulation
  • Dairy Products / microbiology
  • Endopeptidases / chemistry
  • Genome, Bacterial
  • Humans
  • Peptides / analysis*
  • Peptides / isolation & purification
  • Phylogeny
  • Proteome / analysis*
  • Proteomics / methods
  • Sequence Analysis, DNA

Substances

  • Bacterial Proteins
  • Peptides
  • Proteome
  • Endopeptidases