Abstract
Molecular drug susceptibility testing was performed on skin biopsies from 24 leprosy patients from Guinea-Conakry for the first time. We identified primary drug resistance in 4 cases and a dapsone-resistant cluster caused by the same strain. Primary transmission of drug-resistant Mycobacterium leprae, including a rifampicin-resistant strain, is reported.
Keywords:
Guinea-Conakry; drug resistance; leprosy.
© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected].
MeSH terms
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Antibiotics, Antitubercular / pharmacology*
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Antibiotics, Antitubercular / therapeutic use
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Antitubercular Agents / pharmacology*
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Antitubercular Agents / therapeutic use
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Biopsy
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DNA, Bacterial / genetics
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Dapsone / pharmacology
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Dapsone / therapeutic use
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Drug Resistance, Microbial*
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Female
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Genome, Bacterial
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Guinea / epidemiology
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Humans
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Leprosy / epidemiology
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Leprosy / microbiology*
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Leprosy / transmission*
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Male
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Mycobacterium leprae / drug effects*
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Mycobacterium leprae / genetics
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Mycobacterium leprae / isolation & purification
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Rifampin / pharmacology
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Rifampin / therapeutic use
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Sequence Analysis, DNA
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Skin / microbiology
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Skin / pathology
Substances
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Antibiotics, Antitubercular
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Antitubercular Agents
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DNA, Bacterial
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Dapsone
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Rifampin