Abstract
To identify the prognostic value of c-jun, c-fos, and p53 in oral cancer, we examined the impact of immunohistochemical expression of these markers on tumor progression in 157 oral squamous cell carcinoma (OSCC). We found that c-jun or c-fos was significantly associated with lymph node metastasis, and coexpression of c-jun/c-fos, or c-jun/c-fos/p53 were significantly associated with lymph node metastasis, poor differentiation and clinical stage. The coexpression of c-jun/c-fos/p53 was identified as independent prognostic factors for overall survival. Simultaneous coexpression of these markers in OSCCs might prove to be a useful indicator for differentiation of low and high-risk patients.
Keywords:
Oral squamous cell carcinoma; c-fos; c-jun; p53.
MeSH terms
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Adult
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Aged
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Biomarkers, Tumor*
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Carcinoma, Squamous Cell / diagnosis
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Carcinoma, Squamous Cell / metabolism*
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Carcinoma, Squamous Cell / mortality*
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Female
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Follow-Up Studies
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Gene Expression
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Humans
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Immunohistochemistry
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Lymphatic Metastasis
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Male
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Middle Aged
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Mouth Neoplasms / diagnosis
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Mouth Neoplasms / metabolism*
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Mouth Neoplasms / mortality*
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Neoplasm Staging
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Prognosis
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Proto-Oncogene Proteins c-fos / genetics
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Proto-Oncogene Proteins c-fos / metabolism*
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Proto-Oncogene Proteins c-jun / genetics
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Proto-Oncogene Proteins c-jun / metabolism*
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Tumor Suppressor Protein p53 / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Biomarkers, Tumor
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Proto-Oncogene Proteins c-fos
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Proto-Oncogene Proteins c-jun
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Tumor Suppressor Protein p53