Comparison of peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men

Cytokine. 2016 Dec:88:51-56. doi: 10.1016/j.cyto.2016.08.017. Epub 2016 Aug 23.

Abstract

The aim of the present cross-sectional retrospective study was to compare the peri-implant clinical and radiographic inflammatory parameters and whole salivary destructive inflammatory cytokine profile among obese and non-obese men. Thirty-five obese and 37 non-obese men were included. Information regarding age, obesity, systemic health status, and habits was collected using a questionnaire. Clinical examination to evaluate peri-implant parameters and radiographic examination to assess marginal bone loss were conducted. Levels of interleukin (IL)-6 and IL-1β in collected un-stimulated whole saliva were measured using enzyme-linked immunosorbent assay. Data was statistically analyzed using Kruskal Wallis test. The mean scores of peri-implant bleeding on probing (P<0.05) and peri-implant probing depth (P<0.05) were significantly higher among obese compared with non-obese individuals. The mean marginal bone loss was also statistically significantly higher among individuals in the test-group compared with the control-group (P<0.05). Whole salivary IL-1β (P<0.001) and IL-6 (P<0.001) levels were significantly higher among individuals in the test-group compared with the control-group. Clinical and radiographic peri-implant inflammatory parameters were worse, and whole salivary IL-6 and IL-1β were higher in obese than non-obese subjects. Obese patients are at greater risk of peri-implant inflammation than non-obese healthy subjects. It is highly recommended that clinicians should educate obese patients seeking implant treatment regarding the association between obesity and peri-implant inflammation. In addition, obese patients with osseointegrated implants must follow strict oral hygiene regimen to prevent inflammation and maintain optimum peri-implant tissue health.

Keywords: Bleeding on probing; Bone loss; Cytokine; Dental implant; Inflammation; Obesity.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alveolar Bone Loss / metabolism*
  • Alveolar Bone Loss / pathology
  • Cross-Sectional Studies
  • Dental Implants / adverse effects
  • Humans
  • Inflammation / metabolism
  • Inflammation / pathology
  • Interleukin-1beta / metabolism*
  • Interleukin-6 / metabolism*
  • Male
  • Middle Aged
  • Obesity / metabolism*
  • Obesity / pathology
  • Retrospective Studies
  • Saliva / metabolism*
  • Salivary Proteins and Peptides / metabolism*

Substances

  • Dental Implants
  • IL1B protein, human
  • IL6 protein, human
  • Interleukin-1beta
  • Interleukin-6
  • Salivary Proteins and Peptides