Nimodipine does not improve neurologic outcome after 14 minutes of cardiac arrest in cats

Stroke. 1989 Aug;20(8):1044-50. doi: 10.1161/01.str.20.8.1044.

Abstract

We tested the effects of nimodipine upon neurologic outcome in 31 cats subjected to 14 minutes of cardiac arrest followed by resuscitation. With the dose schedule used, nimodipine had no effect upon neurologic outcome or upon the percentage of ischemic neurons in frontal, hippocampal, occipital, or cerebellar brain sections. The electroencephalographic recovery pattern did not correlate with neurologic or pathologic findings.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain / pathology
  • Cats
  • Central Nervous System Diseases / prevention & control*
  • Electroencephalography
  • Heart Arrest / drug therapy*
  • Nimodipine / therapeutic use*
  • Resuscitation*
  • Time Factors

Substances

  • Nimodipine