Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans

Suk-Kyun Yang; Myunghee Hong; Hyunjung Oh; Hui-Qi Low; Seulgi Jung; Seonjoo Ahn; Youngjin Kim; Jiwon Baek; Cue Hyunkyu Lee; Eunji Kim; Kyung Mo Kim; Byong Duk Ye; Kyung-Jo Kim; Sang Hyoung Park; Ho-Su Lee; Inchul Lee; Hyoung Doo Shin; Buhm Han; Dermot P B McGovern; Jianjun Liu; Kyuyoung Song

doi:10.1053/j.gastro.2016.08.025

Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans

Gastroenterology. 2016 Dec;151(6):1096-1099.e4. doi: 10.1053/j.gastro.2016.08.025. Epub 2016 Aug 26.

Authors

Suk-Kyun Yang¹, Myunghee Hong², Hyunjung Oh², Hui-Qi Low², Seulgi Jung², Seonjoo Ahn², Youngjin Kim², Jiwon Baek², Cue Hyunkyu Lee³, Eunji Kim⁴, Kyung Mo Kim⁵, Byong Duk Ye¹, Kyung-Jo Kim¹, Sang Hyoung Park¹, Ho-Su Lee¹, Inchul Lee⁶, Hyoung Doo Shin⁷, Buhm Han³, Dermot P B McGovern⁸, Jianjun Liu⁹, Kyuyoung Song¹⁰

Affiliations

¹ Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
² Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.
³ Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
⁴ Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea; Asan Institute for Life Sciences, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea; Department of Chemistry, Seoul National University, Seoul, Korea.
⁵ Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
⁶ Department of Pathology, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
⁷ Department of Life Science, Sogang University, Seoul, Korea.
⁸ The F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
⁹ Human Genetics Group, Genome Institute of Singapore, Singapore.
¹⁰ Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address: [email protected].

PMID: 27569725
DOI: 10.1053/j.gastro.2016.08.025

Abstract

Recent genome-wide association studies have identified more than 200 regions that affect susceptibility to inflammatory bowel disease (IBD). However, identified common variants account for only a fraction of IBD heritability and largely have been identified in populations of European ancestry. We performed a genome-wide association study of susceptibility loci in Korean individuals, comprising a total of 1505 IBD patients and 4041 controls. We identified 2 new susceptibility loci for IBD at genome-wide significance: rs3766920 near PYGO2-SHC1 at 1q21 and rs16953946 in CDYL2 at 16q23. In addition, we confirmed associations, in Koreans, with 28 established IBD loci (P < 2.16 × 10^-4). Our findings support the complementary value of genetic studies in different populations.

Keywords: Crohn’s Disease; Genetics; Risk Factor; Ulcerative Colitis.

MeSH terms

Adolescent
Adult
Asian People / genetics*
Case-Control Studies
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 16*
Colitis, Ulcerative / diagnosis
Colitis, Ulcerative / genetics*
Crohn Disease / diagnosis
Crohn Disease / genetics*
Genetic Loci
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Intracellular Signaling Peptides and Proteins / genetics
Likelihood Functions
Polymorphism, Single Nucleotide
Republic of Korea
Src Homology 2 Domain-Containing, Transforming Protein 1 / genetics
Young Adult

Substances

Intracellular Signaling Peptides and Proteins
PYGO2 protein, human
SHC1 protein, human
Src Homology 2 Domain-Containing, Transforming Protein 1