Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet

Ding-Kun Ji; Yue Zhang; Yi Zang; Jia Li; Guo-Rong Chen; Xiao-Peng He; He Tian

doi:10.1002/adma.201602748

Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet

Adv Mater. 2016 Nov;28(42):9356-9363. doi: 10.1002/adma.201602748. Epub 2016 Aug 29.

Authors

Ding-Kun Ji¹, Yue Zhang^{1

2}, Yi Zang², Jia Li², Guo-Rong Chen¹, Xiao-Peng He¹, He Tian¹

Affiliations

¹ Key Laboratory for Advanced Materials and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai, 200237, P. R. China.
² National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 189 Guo Shoujing Rd., Shanghai, 201203, P. R. China.

PMID: 27570946
DOI: 10.1002/adma.201602748

Abstract

A 2D "glycosheet" based on supramolecular self-assembly between 2D MoS₂ and fluorescent glycoligands is developed. The composite 2D material is proven suitable for targeted intracellular production of reactive oxygen species (singlet oxygen) by the sequential control of a receptor endocytosis and light irradiation.

Keywords: 2D molybdenum disulfide; graphene analogues; imaging; ractive oxygen species (RO)S; receptors.