Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines

Molecules. 2016 Aug 26;21(9):1125. doi: 10.3390/molecules21091125.

Abstract

Three new triterpenoid alkaloids, namely buxmicrophyllines P-R (1-3), were isolated from the twigs and leaves of Buxus microphylla. Their structures were elucidated on the basis of NMR and MS spectroscopic analyses. Structurally, compounds 1-3 belong to the 9,10-cycloartane type alkaloids. In addition, compound 3 exhibited moderate cytotoxic activities in vitro against HL-60, SMMC-7221, A-549, MCF-7, and SW480 cell lines (with IC50 values ranging from 4.51 to 15.58 μM).

Keywords: Buxus microphylla; cytotoxicity; triterpenoid alkaloid.

MeSH terms

  • A549 Cells
  • Alkaloids* / chemistry
  • Alkaloids* / isolation & purification
  • Alkaloids* / pharmacology
  • Antineoplastic Agents, Phytogenic* / chemistry
  • Antineoplastic Agents, Phytogenic* / isolation & purification
  • Antineoplastic Agents, Phytogenic* / pharmacology
  • Buxus / chemistry*
  • Cytotoxins* / chemistry
  • Cytotoxins* / isolation & purification
  • Cytotoxins* / pharmacology
  • HL-60 Cells
  • Humans
  • MCF-7 Cells
  • Triterpenes* / chemistry
  • Triterpenes* / isolation & purification
  • Triterpenes* / pharmacology

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Triterpenes