The number of people having a chronic disease is increasing. Telehealth may provide an alternative to traditional medicine as telehealth solutions have shown to have a positive influence on quality of live and to decrease the number of hospital visits. A new telehealth solution is the eWALL system. Previously, the eWALL interface application has been evaluated using participatory heuristic evaluation (PHE). The previous round of PHE lead to drastic changes of the eWALL interface application. Consequently, a second round of PHE was performed. Five usability experts and two work-domain professionals inspected the eWALL interface application and identified usability problems (n = 384). The work domain professionals had a tendency to use other heuristics than the usability experts highlighting the relevance of using PHE in an interface development process.