Poorer Prognosis of Primary Signet-Ring Cell Carcinoma of the Breast Compared with Mucinous Carcinoma

Xiufeng Wu; Zhenzhen Zhang; Xin Li; Qingzhong Lin; Gang Chen; Jianping Lu; Yi Zeng; Dan Hu; Kai Huang; Zhiwu Lin; Jun Yan

doi:10.1371/journal.pone.0162088

Poorer Prognosis of Primary Signet-Ring Cell Carcinoma of the Breast Compared with Mucinous Carcinoma

PLoS One. 2016 Sep 1;11(9):e0162088. doi: 10.1371/journal.pone.0162088. eCollection 2016.

Authors

Xiufeng Wu¹, Zhenzhen Zhang², Xin Li³, Qingzhong Lin¹, Gang Chen⁴, Jianping Lu⁴, Yi Zeng¹, Dan Hu⁴, Kai Huang¹, Zhiwu Lin⁵, Jun Yan^{1

6}

Affiliations

¹ Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian, People's Republic of China.
² Department of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350014, Fujian, People's Republic of China.
³ Fujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou 350014, Fujian, People's Republic of China.
⁴ Department of Pathology, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian, People's Republic of China.
⁵ Department of Surgery, Fujian Provincial Hospital, Teaching Hospital of Fujian Medical University, Fuzhou 350014, Fujian, People's Republic of China.
⁶ Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P.R. China.

Abstract

Our results confirmed the more aggressive behavior of PSRCC compared to MBC. This tumor is frequently associated with more frequent lymphatic metastasis, higher Ki67 labeling index, more advanced stage disease as well as simultaneous vimentin upregulation and E-cadherin downregulation. Different management guidelines should be considered for the two types.

Publication types

Comparative Study

MeSH terms

Adult
Aged
Breast Neoplasms / diagnosis*
Breast Neoplasms / metabolism*
Breast Neoplasms / pathology
Carcinoma, Signet Ring Cell / diagnosis*
Carcinoma, Signet Ring Cell / metabolism
Carcinoma, Signet Ring Cell / pathology
Epithelial-Mesenchymal Transition
Humans
Lymphatic Metastasis
Middle Aged
Mucins / metabolism*
Neoplasm Staging
Prognosis
Retrospective Studies

Substances

Mucins

Grants and funding

This work was supported by the Natural Science Foundation of Fujian Province (2014J01300, 2016J01508), the Program from Education Bureau of Fujian Province (JB13127), the Special Fund for Guangdong Province Public Research and Capacity Building (2014B020215002), the Natural Science Foundation of Guangdong Province (2015A030308006), the National clinical key specialty construction program, the Innovation Research of Fujian Health Bureau (2012-CXB-7), the High Level Research Matching Foundation of Nanfang Hospital, and the Scientific Research Foundation for High Level Talents in Nanfang Hospital of Southern Medical University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.