Abstract
Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.
MeSH terms
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Agaricales / chemistry*
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Animals
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Astrocytes / drug effects
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Brain-Derived Neurotrophic Factor / agonists*
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Germany
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Humans
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Molecular Structure
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Nerve Growth Factors / agonists*
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Nerve Tissue Proteins
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Nuclear Magnetic Resonance, Biomolecular
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PC12 Cells
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Rats
Substances
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Benzofurans
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Nerve Tissue Proteins
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corallocin A
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corallocin B
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corallocin C