Cytotoxic limonoids from the root bark of Dictamnus angustifolius

Jian-Bo Sun; Ben-Qin Tang; Qiangqiang Li; Bing Wang; Jing-Yu Liang; Li Chen

doi:10.1016/j.fitote.2016.09.001

Cytotoxic limonoids from the root bark of Dictamnus angustifolius

Fitoterapia. 2016 Dec:115:92-95. doi: 10.1016/j.fitote.2016.09.001. Epub 2016 Sep 4.

Authors

Jian-Bo Sun¹, Ben-Qin Tang², Qiangqiang Li¹, Bing Wang¹, Jing-Yu Liang³, Li Chen⁴

Affiliations

¹ Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
² Department of Medical Science, Shunde Polytechnic College, Shunde, Guangdong 528333, China.
³ Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: [email protected].
⁴ Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: [email protected].

PMID: 27601203
DOI: 10.1016/j.fitote.2016.09.001

Abstract

Three novel limonoids, dictangustone G (1), dictangustone H (2), and dictangustone I (3) were isolated from the root bark of Dictamnus angustifolius. Their structures were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR spectroscopic experiments. Compounds 1-3 were evaluated for their cytotoxic activities using Hela, A549, MCF7, and LN229 cell lines.

Keywords: Cytotoxic activities; Dictamnus angustifolius; Limonoids.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Cell Line, Tumor
Dictamnus / chemistry*
Humans
Limonins / chemistry*
Limonins / isolation & purification
Molecular Structure
Plant Bark / chemistry
Plant Roots / chemistry

Substances

Antineoplastic Agents, Phytogenic
Limonins