Feasibility and applicability of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in routine assessments of children with high-grade gliomas

Pediatr Blood Cancer. 2017 Feb;64(2):279-283. doi: 10.1002/pbc.26216. Epub 2016 Sep 12.

Abstract

Diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) have been used as imaging biomarkers in adults with high-grade gliomas (HGGs). We incorporated free-breathing DW-MRI and DCE-MRI, at a single time point, in the routine follow-up of five children (median age 9 years, range 8-15) with histologically confirmed HGG within a prospective imaging study. It was feasible to incorporate DW-MRI and DCE-MRI in routine assessments of children with HGG. DW and DCE parameters were repeatable in paediatric HGG. Higher median ADC100-1000 significantly correlated with longer survival in our sample.

Keywords: diffusion-weighted; dynamic contrast-enhanced; functional imaging; high-grade glioma; magnetic resonance; paediatric.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / diagnostic imaging
  • Child
  • Contrast Media*
  • Diffusion Magnetic Resonance Imaging / methods*
  • Feasibility Studies
  • Female
  • Follow-Up Studies
  • Glioma / diagnosis*
  • Glioma / diagnostic imaging
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Male
  • Neoplasm Grading
  • Prognosis
  • Young Adult

Substances

  • Contrast Media