Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome

Adv Mater. 2016 Nov;28(43):9486-9490. doi: 10.1002/adma.201603270. Epub 2016 Sep 12.

Abstract

The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, a layer-by-layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL-probiotics in vivo.

Keywords: biomaterials; gastrointestinal tract; microbiome; oral delivery.

MeSH terms

  • Animals
  • Bacillus coagulans* / cytology
  • Bacillus coagulans* / growth & development
  • Bacillus coagulans* / isolation & purification
  • Bacillus coagulans* / metabolism
  • Bacterial Adhesion
  • Bile Acids and Salts / metabolism
  • Bile Acids and Salts / pharmacology
  • Drug Compounding*
  • Gastrointestinal Microbiome* / physiology
  • Humans
  • Intestinal Mucosa / metabolism*
  • Intestines / drug effects
  • Intestines / microbiology
  • Probiotics / administration & dosage*
  • Probiotics / chemistry*
  • Probiotics / pharmacokinetics
  • Swine

Substances

  • Bile Acids and Salts