1 College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
2 School of Clinical and Experimental Medicine, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
3 Division of Health and Social Care, Faculty of Life Sciences and Medicine, King's College, 7th Floor Capital House, 42 Weston Street, London SE1 3QD, UK.