Objective: The aim of the study was to examine the prevalence of protein-energy wasting (PEW) in hemodialysis (HD) and peritoneal dialysis (PD) patients in our center and determine whether adiponectin and leptin are involved in the development of PEW.
Design: Prospective (18 months).
Setting: University Hospital of Heraklion, Crete, Greece.
Subjects: Seventy-four end-stage-renal-disease patients, 47 on HD and 27 on PD.
Main outcome measures: At three sequential time points (baseline, 6 and 18 months) anthropometric, nutritional and inflammatory status data were collected. Serum adiponectin and leptin were also assessed at each time point. Patients were allocated to 3 strata according to PEW severity (0, 1-2 and ≥3 criteria for PEW).
Results: Adiponectin and leptin levels were greater among PD compared to HD patients (p≤0.035). Adiponectin levels were incrementally greater across increasing strata of PEW (p≤0.002). Leptin showed the opposite trend, with lower levels in malnourished patients and higher levels in patients with zero PEW criteria (p≤0.042). Alterations of adiponectin levels during the observation period were dependent on PEW stratum (p≤0.021) and mode of dialysis (p≤0.002), after adjustment for age, dialysis vintage, gender and fat mass index. Particularly, adiponectin levels increased over time in HD patients with ≥3 criteria for PEW, whereas adiponectin levels decreased in PD patients with ≥3 criteria for PEW throughout the study. Leptin alterations over time were not affected by dialysis mode or PEW stratification.
Conclusions: Our study provides evidence that increased adiponectin and decreased leptin levels are independently associated with PEW and thus, poor prognosis.
Keywords: Adipocitos; Adipocytes; CKD; Desgaste proteico-energético; Kidney disease; Malnutrición; Malnutrition; Mortalidad; Mortality; Nefropatía; Protein-energy wasting; Renal disease.
Copyright © 2016 SEEN. Publicado por Elsevier España, S.L.U. All rights reserved.