1 Department of Anaesthesiology, Copenhagen University Hospital, Capital Region of Denmark, Nordsjællands Hospital, Hillerød, Denmark, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, [email protected] Department of Anaesthesiology, Copenhagen University Hospital, Capital Region of Denmark, Nordsjællands Hospital, Hillerød, Denmark Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Anaesthesiology and Intensive Care, Section South, Aarhus University Hospital, Aarhus, Denmark Department of Anaesthesiology, Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Department of Anaesthesiology, Copenhagen University Hospital, Capital Region of Denmark, Nordsjællands Hospital, Hillerød, Denmark.