Use of Dithiothreitol to Dislodge Bacteria From the Biofilm on an Aortic Valve in the Operating Theatre: A Case of Infective Endocarditis Caused by Staphylococcus aureus and Proteus mirabilis

Ann Thorac Surg. 2016 Oct;102(4):e357-9. doi: 10.1016/j.athoracsur.2016.03.023.

Abstract

This is the first reported case of 2 biofilm-producing bacteria, Staphylococcus aureus and Proteus mirabilis, identified from an aortic valve using an innovative device with dithiothreitol solution, able to dislodge bacterial biofilm. The method is usable in the operating theatre and recommended in infective endocarditis nonresponders to empiric therapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aortic Valve / drug effects
  • Aortic Valve / microbiology*
  • Aortic Valve / surgery
  • Biofilms / drug effects*
  • Echocardiography, Transesophageal / methods
  • Endocarditis, Bacterial / diagnostic imaging*
  • Endocarditis, Bacterial / drug therapy*
  • Endocarditis, Bacterial / etiology
  • Endocarditis, Bacterial / surgery
  • Follow-Up Studies
  • Humans
  • Male
  • Operating Rooms
  • Proteus mirabilis / drug effects*
  • Proteus mirabilis / physiology
  • Risk Assessment
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / physiology
  • Substance-Related Disorders / complications
  • Treatment Outcome