Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas

Acta Neuropathol. 2016 Nov;132(5):761-763. doi: 10.1007/s00401-016-1619-0. Epub 2016 Sep 20.

Authors

Fausto J Rodriguez^{1

2}, M Adelita Vizcaino³, Jaishri Blakeley^{4

5}, Christopher M Heaphy^{3

4}

Affiliations

¹ Department of Pathology, Johns Hopkins University, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA. [email protected].
² Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA. [email protected].
³ Department of Pathology, Johns Hopkins University, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA.
⁴ Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
⁵ Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.

PMID: 27650176
DOI: 10.1007/s00401-016-1619-0

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics
Adolescent
Adult
Brain Neoplasms / genetics*
Brain Neoplasms / metabolism*
Brain Neoplasms / pathology
Child
Child, Preschool
Co-Repressor Proteins
Female
Humans
In Situ Hybridization, Fluorescence
Isocitrate Dehydrogenase / genetics
Male
Middle Aged
Molecular Chaperones
Neoplasms, Neuroepithelial / genetics*
Neoplasms, Neuroepithelial / metabolism
Neoplasms, Neuroepithelial / pathology
Neurofibromatosis 1 / complications
Neurofibromatosis 1 / genetics*
Nuclear Proteins / genetics
Telomere / pathology*
Telomere Homeostasis / genetics*
X-linked Nuclear Protein / genetics
X-linked Nuclear Protein / metabolism*
Young Adult

Substances

Adaptor Proteins, Signal Transducing
Co-Repressor Proteins
DAXX protein, human
Molecular Chaperones
Nuclear Proteins
Isocitrate Dehydrogenase
ATRX protein, human
X-linked Nuclear Protein