CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

Gabriele Valentini; Antonella Riccardi; Serena Vettori; Rosaria Irace; Michele Iudici; Salvatore Tolone; Ludovico Docimo; Marialuisa Bocchino; Alessandro Sanduzzi; Domenico Cozzolino

doi:10.1007/s10238-016-0437-y

CXCL4 in undifferentiated connective tissue disease at risk for systemic sclerosis (SSc) (previously referred to as very early SSc)

Clin Exp Med. 2017 Aug;17(3):411-414. doi: 10.1007/s10238-016-0437-y. Epub 2016 Sep 20.

Authors

Gabriele Valentini^{1

2

3}, Antonella Riccardi^{4

5

6}, Serena Vettori^{4

5

6}, Rosaria Irace^{4

5

6}, Michele Iudici^{4

5

6}, Salvatore Tolone^{4

5

6}, Ludovico Docimo^{4

5

6}, Marialuisa Bocchino^{4

5

6}, Alessandro Sanduzzi^{4

5

6}, Domenico Cozzolino^{4

5

6}

Affiliations

¹ Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy. [email protected].
² Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy. [email protected].
³ Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy. [email protected].
⁴ Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.
⁵ Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.
⁶ Division of Respiratory Disease, Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

PMID: 27650429
DOI: 10.1007/s10238-016-0437-y

Abstract

The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients. Further studies are needed to investigate the role of CXCL4 assessment in UCTD-risk-SSc.

Keywords: Systemic sclerosis; Undifferentiated connective tissue disease.

MeSH terms

Adult
Female
Humans
Male
Middle Aged
Platelet Factor 4 / blood*
Prognosis
Scleroderma, Systemic / diagnosis*
Scleroderma, Systemic / pathology*
Undifferentiated Connective Tissue Diseases / complications*
Undifferentiated Connective Tissue Diseases / diagnosis
Undifferentiated Connective Tissue Diseases / pathology*

Substances

Platelet Factor 4