Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

S Kasar; J R Brown

doi:10.1080/23723556.2016.1157667

Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia

Mol Cell Oncol. 2016 Mar 10;3(4):e1157667. doi: 10.1080/23723556.2016.1157667. eCollection 2016 Jul.

Authors

S Kasar¹, J R Brown¹

Affiliation

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Abstract

Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes-2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature-that operate at different times throughout CLL evolution.

Keywords: CLL; Whole genome sequencing; mutation signature; somatic hypermutation.