Pd-Catalyzed Carboamination of Alkylidenecyclopropanes: Synthesis of Congested Pyrrolidines and Piperidines

Phillip R Lazzara; Keegan P Fitzpatrick; Chad C Eichman

doi:10.1002/chem.201604077

Pd-Catalyzed Carboamination of Alkylidenecyclopropanes: Synthesis of Congested Pyrrolidines and Piperidines

Chemistry. 2016 Nov 14;22(47):16779-16782. doi: 10.1002/chem.201604077. Epub 2016 Oct 11.

Authors

Phillip R Lazzara¹, Keegan P Fitzpatrick¹, Chad C Eichman¹

Affiliation

¹ Department of Chemistry and Biochemistry, Loyola University Chicago, 1068 West Sheridan Road, Chicago, IL, 60660, USA.

PMID: 27661456
DOI: 10.1002/chem.201604077

Abstract

The synthesis of densely functionalized N-heterocycles is an ongoing challenge in chemical synthesis. Herein, we report an efficient method for the construction of pyrrolidine and piperidine scaffolds using a palladium-catalyzed carboamination of alkylidenecyclopropanes.

Keywords: aminoarylation; carboamination; homogeneous catalysis; nitrogen heterocycles; palladium catalysis.