Lifting the Differentiation Embargo

Anne-Louise Latif; Tessa L Holyoake

doi:10.1016/j.cell.2016.08.051

Lifting the Differentiation Embargo

Cell. 2016 Sep 22;167(1):45-46. doi: 10.1016/j.cell.2016.08.051.

Authors

Anne-Louise Latif¹, Tessa L Holyoake²

Affiliations

¹ Department of Haematology, Glasgow Royal Infirmary, 84 Castle Street, Glasgow G4 OSF, UK. Electronic address: [email protected].
² Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G12 OZD, UK. Electronic address: [email protected].

PMID: 27662083
DOI: 10.1016/j.cell.2016.08.051

Abstract

Effective differentiation therapy for acute myeloid leukemia (AML) has been restricted to a small subset of patients with one defined genetic abnormality. Using an unbiased small molecule screen, Sykes et al. now identify a mechanism of de-repression of differentiation in several models of AML driven by distinct genetic drivers.

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MeSH terms

Cell Differentiation
Humans
Leukemia, Myeloid, Acute / genetics*
Lifting*