At odds with its nuclear counterpart, extranuclear promyelocytic leukemia constitutively inhibits autophagy, hence limiting cancer progression. These data raise the interesting possibility that some tumor suppressors have become specialized to operate at multiple subcellular compartments for counteracting different aspects of the oncogenic process.
Keywords: MAMs; autophagy; beclin 1; chloroquine; p53; regulated cell death.
Copyright © 2016 Elsevier Ltd. All rights reserved.