Familial aortic valve disease: evidence for a genetic influence?

Eur Heart J. 1989 Jul;10(7):676-7. doi: 10.1093/oxfordjournals.eurheartj.a059546.

Abstract

It has been suggested that genetic factors may play a role in the aetiology of congenital bicuspid aortic valve disease. This report describes a family in which three male siblings with bicuspid aortic valves developed critical aortic stenosis. This provides further evidence that an hereditary mechanism may play a role in some patients with this condition.

MeSH terms

  • Adult
  • Aortic Valve
  • Aortic Valve Stenosis / etiology
  • Genetic Diseases, Inborn / etiology*
  • Heart Valve Diseases / complications
  • Heart Valve Diseases / congenital
  • Heart Valve Diseases / etiology*
  • Humans
  • Male