The battlefield in the war against attaching-and-effacing bacterial pathogens: Monocytes, macrophages and dendritic cells in action

Vet Microbiol. 2017 Apr:202:47-51. doi: 10.1016/j.vetmic.2016.09.007. Epub 2016 Sep 20.

Abstract

The recent adoption of a unified nomenclature for the mononuclear phagocyte system has already led to the generation of novel strategies for specifically depleting a single subset of phagocytes in the presence of intact lymphoid structures. Herein, we provide a detailed description of how the various types of tissue phagocyte orchestrate the host's defense against enteric bacterial infections. From a bench-to-bedside perspective, we expect that this paradigm will accelerate the development of novel adjuvants and vaccines in human and veterinary microbiology.

Keywords: Dendritic cell; Enteric bacterial infection; Macrophage; Monocyte.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Animals
  • Bacterial Adhesion / physiology*
  • Dendritic Cells / physiology*
  • Humans
  • Macrophages / physiology*
  • Monocytes / physiology*
  • Mononuclear Phagocyte System / physiology*