Post-Kala-Azar Dermal Leishmaniasis Without Previous History of Visceral Leishmaniasis

Golam Hasnain; Mohammad Sohel Shomik; Prakash Ghosh; Mamun Or Rashid; Shakhawat Hossain; Shinjiro Hamano; Dinesh Mondal

doi:10.4269/ajtmh.16-0230

Post-Kala-Azar Dermal Leishmaniasis Without Previous History of Visceral Leishmaniasis

Am J Trop Med Hyg. 2016 Dec 7;95(6):1383-1385. doi: 10.4269/ajtmh.16-0230. Epub 2016 Sep 26.

Authors

Golam Hasnain^{1

2}, Mohammad Sohel Shomik², Prakash Ghosh², Mamun Or Rashid², Shakhawat Hossain², Shinjiro Hamano³, Dinesh Mondal⁴

Affiliations

¹ Centre for Clinical Epidemiology and Biostatistics (CCEB), School of Medicine and Public Health, Faculty of Health and Medicine, The University of Newcastle (UoN), New South Wales, Australia.
² Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
³ Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
⁴ Nutrition and Clinical Services Division (NCSD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. [email protected].

Abstract

Post-kala-azar dermal leishmaniasis (PKDL) without previous visceral leishmaniasis (VL) is a rare dermatological manifestation of Leishmania infection. To date, most of the reported cases neither showed parasitological confirmation nor explained the outcome of treatment. Herein, we report three confirmed cases that were were successfully cured after miltefosine treatment.

Publication types

Case Reports

MeSH terms

Adolescent
Adult
Antiprotozoal Agents / therapeutic use
DNA, Protozoan / isolation & purification
Female
Humans
Leishmania donovani / genetics
Leishmaniasis, Cutaneous / complications*
Leishmaniasis, Visceral / complications*
Male
Phosphorylcholine / analogs & derivatives
Phosphorylcholine / therapeutic use
Polymerase Chain Reaction

Substances

Antiprotozoal Agents
DNA, Protozoan
Phosphorylcholine
miltefosine