Blood flow boosts BMP signaling to keep vessels in shape

J Cell Biol. 2016 Sep 26;214(7):793-5. doi: 10.1083/jcb.201609038.

Abstract

Bone morphogenic proteins (BMPs) and blood flow regulate vascular remodeling and homeostasis. In this issue, Baeyens et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201603106) show that blood flow sensitizes endothelial cells to BMP9 signaling by triggering Alk1/ENG complexing to suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Vessels / metabolism*
  • Blood Vessels / pathology*
  • Bone Morphogenetic Proteins / metabolism*
  • Mice
  • Models, Biological
  • Regional Blood Flow
  • Signal Transduction*

Substances

  • Bone Morphogenetic Proteins