Quality of life and functional status of terminally ill head and neck cancer patients: a nation-wide, prospective observational study at tertiary cancer centers in Japan

Jpn J Clin Oncol. 2017 Jan;47(1):47-53. doi: 10.1093/jjco/hyw138. Epub 2016 Sep 27.

Abstract

Background: Little is known about quality of life and functional status of patients with terminally ill head and neck cancers.

Methods: We conducted a multicenter, prospective, observational study to examine quality of life and functional status in terminally ill head and neck cancer patients.

Results: Of the 100 patients meeting inclusion criteria, 72 were observed until death. There was no significant difference in the quality of life score between baseline and Week 3. Forty patients (54.9%) could speak and 22 patients (30.5%) could have oral intake upon study entry. Fifty-three patients (74.6%) received enteral nutrition. Twenty-six patients (36.6%) required dressing changes for fungating tumors. The route of nutritional intake (nasogastric tube vs. percutaneous gastric tube) might be predictive for the duration of hospital stay (64 vs. 21 days, P = 0.0372).

Conclusion: There was no significant relationship between quality of life and functional status seen in this study. Feeding tube type could have the most impact on quality of life.

Keywords: functional status; head and neck cancer; nutrition; prospective observation; terminally ill.

Publication types

  • Multicenter Study
  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Enteral Nutrition
  • Female
  • Head and Neck Neoplasms / mortality
  • Head and Neck Neoplasms / pathology*
  • Health Status
  • Humans
  • Intubation, Gastrointestinal
  • Japan
  • Length of Stay
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Survival Rate
  • Terminally Ill
  • Tertiary Care Centers