Abstract
A pair of enantiomers and a pair of 2,3-dihydro-1H-indene epimers, rac-indidene A (rac-1), indidenes B and C (2, 3); four new coumarin glucosides (4-7); and four known coumarin glucosides (8-11) were isolated from the bark of Streblus indicus (Bur.) Corner. The structures of 1-11 were defined by physical data analyses, including MS, NMR, and single-crystal X-ray diffraction. The absolute configurations of the 2,3-dihydro-1H-indene derivatives were defined via experimental and calculated ECD data. rac-Indidene A and indidenes B and C showed inhibitory activity against A549 and MCF-7 tumor cells with IC50 values in the range of 2.2 ± 0.1 to 7.2 ± 0.9 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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A549 Cells
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Chromatography, High Pressure Liquid
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Humans
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Indenes / chemistry
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Indenes / isolation & purification*
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Indenes / pharmacology*
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Inhibitory Concentration 50
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MCF-7 Cells
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Molecular Structure
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Moraceae / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry*
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Stereoisomerism
Substances
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Coumarins
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Drugs, Chinese Herbal
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Glucosides
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Indenes