TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management

Bernard Thienpont; Eva Galle; Diether Lambrechts

doi:10.2217/epi-2016-0126

TET enzymes as oxygen-dependent tumor suppressors: exciting new avenues for cancer management

Epigenomics. 2016 Nov;8(11):1445-1448. doi: 10.2217/epi-2016-0126. Epub 2016 Oct 13.

Authors

Bernard Thienpont^{1

2}, Eva Galle^{1

2}, Diether Lambrechts^{1

2}

Affiliations

¹ Vesalius Research Center, VIB, 3000 Leuven, Belgium.
² Department of Oncology, Laboratory of Translational Genetics, KU Leuven, 3000 Leuven, Belgium.

PMID: 27733058
DOI: 10.2217/epi-2016-0126

No abstract available

Keywords: TET1; TET2; TET3; antiangiogenic therapy; epigenetic therapy; hypermethylation; hypoxia; oncogenesis; oxygen sensitivity; tumor suppressor genes.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Dioxygenases / genetics
Dioxygenases / metabolism*
Humans
Mixed Function Oxygenases / genetics
Mixed Function Oxygenases / metabolism*
Neoplasms* / enzymology
Neoplasms* / genetics
Neoplasms* / therapy
Oxygen / metabolism*
Proto-Oncogene Proteins / genetics
Proto-Oncogene Proteins / metabolism*
Tumor Suppressor Proteins / genetics
Tumor Suppressor Proteins / metabolism*

Substances

DNA-Binding Proteins
Proto-Oncogene Proteins
Tumor Suppressor Proteins
Mixed Function Oxygenases
TET1 protein, human
TET3 protein, human
Dioxygenases
TET2 protein, human
Oxygen