The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates

Haematologica. 2017 Feb;102(2):e65-e68. doi: 10.3324/haematol.2016.152371. Epub 2016 Oct 14.

Authors

Mohib Uddin¹, Catherine Betts², Ian Robinson³, Anna Malmgren¹, Charles Humfrey³

Affiliations

¹ The IMED Respiratory, Inflammation & Autoimmunity Unit, AstraZeneca Gothenburg, Mölndal, Sweden.
² Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K. [email protected].
³ Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, U.K.

No abstract available

Publication types

Letter

MeSH terms

Administration, Oral
Animals
Chemokine CXCL1 / genetics
Chemokine CXCL1 / immunology
Drug Administration Schedule
Female
Gene Expression Regulation
Granulocyte Colony-Stimulating Factor / genetics
Granulocyte Colony-Stimulating Factor / immunology
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
Granulocyte-Macrophage Colony-Stimulating Factor / immunology
Immunity, Innate / drug effects
Interferon-gamma / genetics
Interferon-gamma / immunology
Interleukin-6 / genetics
Interleukin-6 / immunology
Interleukin-8 / agonists
Interleukin-8 / genetics
Interleukin-8 / immunology*
Leukocyte Count
Macaca fascicularis
Male
Neutrophils / cytology
Neutrophils / drug effects*
Neutrophils / immunology
Phagocytosis / drug effects*
Pyrimidines / pharmacology*
Receptors, Interleukin-8B / antagonists & inhibitors
Receptors, Interleukin-8B / genetics
Receptors, Interleukin-8B / immunology*
Respiratory Burst / drug effects*
Signal Transduction
Sulfonamides / pharmacology*
Toxicity Tests, Chronic
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / immunology

Substances

Chemokine CXCL1
Interleukin-6
Interleukin-8
N-(2-(2,3-difluoro-6-benzylthio)-6-(3,4-dihydroxybutan-2-yloxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Pyrimidines
Receptors, Interleukin-8B
Sulfonamides
Tumor Necrosis Factor-alpha
Granulocyte Colony-Stimulating Factor
Interferon-gamma
Granulocyte-Macrophage Colony-Stimulating Factor