Complimentary Pattern of Uptake in 18F-FDG PET/CT and 68Ga-Prostate-Specific Membrane Antigen PET/CT in a Case of Metastatic Clear Cell Renal Carcinoma

Clin Nucl Med. 2016 Dec;41(12):e517-e519. doi: 10.1097/RLU.0000000000001394.

Abstract

We describe a case of metastatic clear cell renal cell carcinoma with intensely tracer concentrating lesions in left suprarenal region, mediastinal lymph nodes, lytic bone lesions, thyroid nodules, and mild abnormal tracer-avid lung nodules in Ga-prostate-specific membrane antigen (PSMA) PET/CT. On the other hand F-FDG PET/CT showed mild to no significant abnormal uptake in these lesions. Complimentary uptake pattern was observed in Ga-PSMA and F-FDG PET images in thyroid lesions and D5 vertebral lesion. This case highlights the possibilities of imaging clear cell renal cell carcinoma with Ga-PSMA and opens the possibility of treatment with Lu-PSMA.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Carcinoma, Renal Cell / diagnostic imaging*
  • Carcinoma, Renal Cell / pathology
  • Edetic Acid / analogs & derivatives
  • Female
  • Fluorodeoxyglucose F18*
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Kidney Neoplasms / diagnostic imaging*
  • Kidney Neoplasms / pathology
  • Neoplasm Metastasis
  • Oligopeptides
  • Organometallic Compounds*
  • Positron Emission Tomography Computed Tomography
  • Radiopharmaceuticals*
  • Tomography, Emission-Computed, Single-Photon

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • Organometallic Compounds
  • Radiopharmaceuticals
  • gallium 68 PSMA-11
  • Fluorodeoxyglucose F18
  • Edetic Acid