Rapid onset of hemophagocytic lymphohistiocytosis in a patient with refractory chronic lymphocytic leukemia treated with ibrutinib

Leuk Lymphoma. 2017 May;58(5):1258-1261. doi: 10.1080/10428194.2016.1243679. Epub 2016 Oct 17.

Authors

Austin Poole¹, Nicole Girard², Frederic Clayton², Srinivas K Tantravahi¹

Affiliations

¹ a Division of Hematology and Hematologic Malignancies , Huntsman Cancer Hospital, University of Utah , Salt Lake City , UT , USA.
² b Department of Pathology ARUP Laboratories , University of Utah , Salt Lake City , UT , USA.

PMID: 27750463
DOI: 10.1080/10428194.2016.1243679

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Adenine / analogs & derivatives
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Autopsy
Biopsy
Chromosome Aberrations
Drug Resistance, Neoplasm
Fatal Outcome
Gene Rearrangement, B-Lymphocyte
Humans
Immunophenotyping
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell / complications*
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
Lymphohistiocytosis, Hemophagocytic / diagnosis*
Lymphohistiocytosis, Hemophagocytic / etiology*
Male
Middle Aged
Neoplasm Staging
Piperidines
Protein Kinase Inhibitors / adverse effects*
Protein Kinase Inhibitors / therapeutic use
Pyrazoles / adverse effects*
Pyrazoles / therapeutic use
Pyrimidines / adverse effects*
Pyrimidines / therapeutic use
Time Factors

Substances

Piperidines
Protein Kinase Inhibitors
Pyrazoles
Pyrimidines
ibrutinib
Adenine