RIFM fragrance ingredient safety assessment, 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol, CAS Registry Number 42822-86-6

A M Api; D Belsito; S Bhatia; M Bruze; G A Burton Jr; J Buschmann; P Calow; M L Dagli; W Dekant; A D Fryer; L Kromidas; S La Cava; A Lapczynski; D C Liebler; D O'Brien; R Parakhia; T M Penning; V T Politano; G Ritacco; D Salvito; T W Schultz; J Shen; I G Sipes; B Wall; D K Wilcox

doi:10.1016/j.fct.2016.10.009

RIFM fragrance ingredient safety assessment, 2-Hydroxy-α,α,4-trimethylcyclohexanemethanol, CAS Registry Number 42822-86-6

Food Chem Toxicol. 2016 Nov:97S:S209-S215. doi: 10.1016/j.fct.2016.10.009. Epub 2016 Oct 14.

Authors

A M Api¹, D Belsito², S Bhatia³, M Bruze⁴, G A Burton Jr⁵, J Buschmann⁶, P Calow⁷, M L Dagli⁸, W Dekant⁹, A D Fryer¹⁰, L Kromidas³, S La Cava³, A Lapczynski³, D C Liebler¹¹, D O'Brien³, R Parakhia³, T M Penning¹², V T Politano³, G Ritacco³, D Salvito³, T W Schultz¹³, J Shen³, I G Sipes¹⁴, B Wall³, D K Wilcox³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address: [email protected].
² Member RIFM Expert Panel, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY 10032, USA.
³ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.
⁴ Member RIFM Expert Panel, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo SE 20502, Sweden.
⁵ Member RIFM Expert Panel, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI 58109, USA.
⁶ Member RIFM Expert Panel, Fraunhofer Institute for Toxicology and Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany.
⁷ Member RIFM Expert Panel, Humphrey School of Public Affairs, University of Minnesota, 301 19th Avenue South, Minneapolis, MN 55455, USA.
⁸ Member RIFM Expert Panel, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil.
⁹ Member RIFM Expert Panel, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
¹⁰ Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
¹¹ Member RIFM Expert Panel, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA.
¹² Member of RIFM Expert Panel, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA 19104-3083, USA.
¹³ Member RIFM Expert Panel, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN 37996- 4500, USA.
¹⁴ Member RIFM Expert Panel, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, USA.

PMID: 27751857
DOI: 10.1016/j.fct.2016.10.009

No abstract available

Publication types

Review

MeSH terms

Animals
Consumer Product Safety
Cyclohexane Monoterpenes
Cyclohexanes / chemistry
Cyclohexanes / toxicity*
DNA Damage / drug effects
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
Endpoint Determination
Menthol / analogs & derivatives*
Menthol / chemistry
Menthol / toxicity
No-Observed-Adverse-Effect Level
Perfume / chemistry
Perfume / toxicity*
Rats
Risk Assessment
Toxicity Tests / methods*

Substances

Cyclohexane Monoterpenes
Cyclohexanes
Perfume
Menthol
cyclohexylmethanol
terpin