CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells

Haematologica. 2017 Jan;102(1):e17-e21. doi: 10.3324/haematol.2016.154013. Epub 2016 Oct 6.

Haiwei Lian^{1

2

3}, Dun Li^{2

4}, Yun Zhou^{2

5}, Esther Landesman-Bollag⁴, Guanglan Zhang⁶, Nicole M Anderson², Kevin Charles Tang², Justine E Roderick⁷, Michelle A Kelliher⁷, David C Seldin⁴, Hui Fu⁸, Hui Feng^{9

4}

¹ Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China.
² Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA.
³ Department of Neurosurgery, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China.
⁴ Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, MA, USA.
⁵ Department of Gynaecology, Wuhan University Renmin Hospital, Wuhan, Hubei, P.R. China.
⁶ Department of Computer Science, Metropolitan College, Boston University, MA, USA.
⁷ Department of Molecular, Cell and Cancer Biology, University of Massachusetts School of Medicine, Worcester, MA, USA.
⁸ Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P.R. China [email protected] [email protected].
⁹ Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, MA, USA [email protected] [email protected].

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