A new timepiece: an epigenetic mitotic clock

Brock C Christensen; Karl T Kelsey

doi:10.1186/s13059-016-1085-y

A new timepiece: an epigenetic mitotic clock

Genome Biol. 2016 Oct 19;17(1):216. doi: 10.1186/s13059-016-1085-y.

Authors

Brock C Christensen^{1

2}, Karl T Kelsey^{3

4}

Affiliations

¹ Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
² Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA.
³ Department of Epidemiology, Brown University, Providence, RI, 02912, USA. [email protected].
⁴ Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, 02912, USA. [email protected].

Abstract

A new mitotic clock and mathematical approach that incorporates DNA methylation biology common among human cell types provides a new tool for cancer epigenetics research.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Lineage / genetics
CpG Islands / genetics
DNA Methylation / genetics*
Epigenomics*
Genome-Wide Association Study
Humans
Mitosis / genetics*

Abstract

Publication types

MeSH terms

Grants and funding