Abstract
In England in 2015, Shigella sonnei isolates from men who have sex with men produced extended-spectrum β-lactamases and exhibited macrolide resistance. Whole-genome sequencing showed a close relationship among the isolates, which harbored a plasmid that was previously identified in a shigellosis outbreak among this population but has acquired a mobile element.
Keywords:
ESBL; ESBL producers; England; MSM; STIs; Shigella; Shigella sonnei; antimicrobial resistance; bacteria; bacterial infections; extended-spectrum beta-lactamase; men who have sex with men; outbreaks; sexually transmitted infections.
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Drug Resistance, Bacterial*
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Dysentery, Bacillary / drug therapy
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Dysentery, Bacillary / epidemiology*
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Dysentery, Bacillary / history
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Dysentery, Bacillary / microbiology*
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England / epidemiology
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Genome, Bacterial
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History, 21st Century
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Homosexuality, Male*
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Humans
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Macrolides / pharmacology*
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Male
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Microbial Sensitivity Tests
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Phylogeny
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Polymorphism, Single Nucleotide
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Shigella sonnei / classification
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Shigella sonnei / drug effects*
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Shigella sonnei / genetics*
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Whole Genome Sequencing
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beta-Lactamases / biosynthesis
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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Macrolides
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beta-Lactamases