Abstract
Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Ferritins / analysis*
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Ferritins / genetics
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Horses
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Humans
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Mutation
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Oxidoreductases / isolation & purification*
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Protein Conformation
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Rats
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Recombinant Proteins / analysis
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X-Ray Diffraction
Substances
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Recombinant Proteins
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Ferritins
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Oxidoreductases
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ferroxidase II